Research progress on the relationship between the renal toxicity of organic anion transporter 1 and the adefovir dipivoxil

Abstract

The body is exposed to various organic anions, so it is the best way to remove the toxic substances in the body quickly and effectively. Cross epithelial active transport mediated by organic anion transporter is the rate limiting process. Renal secretion and re-absorption of a variety of endogenous and exogenous organic anions are occurred in the proximal tubular epithelial cells of the organic anion transporter family. The expression of organic anion transporter-1 (OAT1) in proximal tubular epithelial cells plays an important role in the introduction of organic anion into the renal tubular epithelial cells. This article reviewed the renal expression, the substrate and the polymorphism of the organic anion transport protein OAT1, the renal toxicity of adefovir dipivoxil, the interaction between organic anion transporters and drug, and the influence of the renal toxicity on the renal toxicity of adefovir dipivoxil. Key words: Organic anion transport protein 1; Phosphonic acids/AE; Adenine/AA/AE; Kidney/ME/PP; Review