Abstract
Background As the spectrum of ophthalmic diseases keeps changing, uveitis has gradually become one of the major blinding eye diseases in the world. In recent years, it has become a research hotspot to select effective components for uveitis treatment from natural drugs. Methods We searched PubMed and EMBASE databases for studies written in English as well as Chinese National Knowledge Infrastructure (CNKI), CQVIP, and Wan Fang database for studies written in Chinese (inception through 30 December 2020). Results Eight kinds of natural product ingredients were included in this article. They were found to not only regulate the expression of cytokines, proliferation, and differentiation of T help cells but also inhibit the damage of cytokines and inflammatory cells to uvea, blood aqueous barrier, and blood retinal barrier. Conclusion Natural product ingredients have their unique advantages in the treatment of uveitis. They have good anti-inflammatory effects without causing serious adverse reactions, which enables them to be promising choices for preventive and therapeutic strategy of uveitis.
Highlights
Uveitis refers to various intraocular inflammatory diseases occurred in uvea and its adjacent structures
The levels of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1β (MIP-1β), tumor cytokine-α (TNF-α), IFN-γ, IL-1β, IL6, IL8, IL-18, and IL-37 were significantly increased in the atrial fluid of patients with uveitis [5,6,7]
Total glucosides of paeony and polyglycosides of Tripterygium wilfordii have good anti-inflammatory activity and are widely used in the clinical treatment of rheumatic immune diseases in China
Summary
Uveitis refers to various intraocular inflammatory diseases occurred in uvea (i.e., iris, ciliary body, and choroid) and its adjacent structures (including cornea, vitreous body, retina, and optic nerve). Oral administration of corticosteroids can inhibit the inflammatory response to the destruction of uveitis, inhibiting the expansion of capillaries and fibroblasts proliferation and differentiation, and can damage the body’s own defense system and affects the ability of the removal of virus infection as well as leading to peptic ulcer, hypertension, and hyperlipidemia. It has become a hot spot in the research field of uveitis to extract immunosuppressive agents with high efficiency and low toxicity from natural drugs. The therapeutic effects of alkaloids, glycosides, polysaccharides, and polyphenols on uveitis and its mechanism were discussed, so as to provide reference for drug development and clinical research
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