Research Progress on the Mechanism of Action of Maxing Shigan Decoction in the Treatment of Viral Pneumonia

Abstract

Viral pneumonia refers to the lung inflammation caused by a viral infection, the main causative agent is Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), Influenza virus (Flu), parainfluenza virus (HPIV), adenovirus (Adv), respiratory syncytial virus (RSV), etc., Its main symptoms are fever, cough, shortness of breath, wheezing and wet lung rales, with changes in chest imaging (X-ray, ultrasound, CT, etc.), For the treatment of viral pneumonia, in addition to the treatment with influenza viruses that can be treated with neuraminidase inhibitors, no specific drugs for other viruses, Clinical mainly symptomatic treatment. Current studies have proved that the inflammatory cytokines IL-6, TNF-α; the stimulating molecule CD137 and the chemokine CXCL-10, and the signaling pathway NF-κB signaling pathway, TLR 4-MyD 88-TRAF-6 pathway effectively inhibit inflammatory response, promote viral clearance, and effectively treat viral pneumonia. Viral pneumonia belongs to the category of "pneumonia asthma" in traditional Chinese medicine. For its heat syndrome and demonstration, such as wind heat, phlegm heat, toxic fever and other syndrome types, it can be used as the basic prescription for addition and subtraction treatment.