Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma

Abstract

Ferroptosis is a new type of programmed cell death discovered in recent years. It is a regulatory cell death induced by iron dependent lipid peroxide injury. Ferroptosis plays a critical role in the development of glioma, affecting tumor proliferation, angiogenesis, tumor cell necrosis, and the formation of an immune-resistant tumor microenvironment. Glioma is the most common intracranial malignant tumor, with the characteristics of high incidence rate, high recurrence rate, high mortality rate and low cure rate. At present, the main standard treatment plan is tumor surgical resection, synchronous radiotherapy and chemotherapy, etc. Because of the extremely low 5-year survival rate and high recurrence rate of glioma patients, new effective treatment strategies are expected. With the extensive study of regulatory cell death in malignant tumors, there is increasing evidence that iron death is closely related to the development and outcome of glioma. Inducing iron death becomes an attractive strategy for glioma treatment. In this paper, we summarize the research on this aspect and summarize it in gelatin. The mechanism of action and therapeutic research value of tumor are expected to develop new therapeutic strategies and provide a certain theoretical basis for the in-depth research in this field.