Research progress on the livin gene and osteosarcomas.

Cheng-Jun Li,Guang-Xin Zhou,Xiao-Zhou Liu,Su-Jia Wu,Meng Lu,Xin Shi,Yu Cong,Xing Zhou

doi:10.7314/apjcp.2014.15.20.8577

Cheng-Jun Li, Guang-Xin Zhou + Show 6 more

Open Access

https://doi.org/10.7314/apjcp.2014.15.20.8577

Copy DOI

Abstract

Osteosarcoma is a common malignant tumor of bone, but mechanisms underlying its development are still unclear. At present, it is believed that the inhibition of normal apoptotic mechanisms is one of the reasons for the development of tumors, so specific stimulation of tumor cell apoptosis can be considered as an important therapeutic method. Livin, as a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has specifically high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment (including osteosarcoma) and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment.

Highlights

Osteosarcoma, as a most common primary malignant tumor of bones, occurs frequently in adolescents with high malignant severity (Bao et al, 2013; He et al, 2013; Jia et al, 2013; Jiang et al, 2013; Jin et al, 2013)
As a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment
8 members of IAPs have been discovered in human body including NAIP, XIAP (ILP-1/MIHA), cIAP-1 (HIAP2/MIHB), Livin (ML-IAP/KIAP), Survivin (TIAP), cIAP-2 (HIAP-1/MI-HC), ILP-2 (Ts-IAP) and Apollon (Bruce) (Zou et al, 2014), in which Livin can be applied as a new target for malignant tumor treatment due to its high expression in tumor tissues

Summary

Introduction

Osteosarcoma, as a most common primary malignant tumor of bones, occurs frequently in adolescents with high malignant severity (Bao et al, 2013; He et al, 2013; Jia et al, 2013; Jiang et al, 2013; Jin et al, 2013). It is commonly found on distal femur and proximal tibia with high rates of recurrence and metastasis and poor prognosis. 8 members of IAPs have been discovered in human body including NAIP, XIAP (ILP-1/MIHA), cIAP-1 (HIAP2/MIHB), Livin (ML-IAP/KIAP), Survivin (TIAP), cIAP-2 (HIAP-1/MI-HC), ILP-2 (Ts-IAP) and Apollon (Bruce) (Zou et al, 2014), in which Livin can be applied as a new target for malignant tumor treatment (including osteosarcoma) due to its high expression in tumor tissues

Structure and Function of Livin

Tissue Distribution and Expression of Livin in Osteosarcoma

Livin and Osteosarcoma Treatment

Conclusions and Prospects