Abstract
Cell cycle checkpoint kinase 2 (Chk2) is a cell cycle monitoring kinase that exists widely in mammals. CHK2 is activated by phosphorylation and has a series of reactions with a variety of downstream proteins, which are active in various cellular reactions of organisms, such as DNA repair, cell cycle regulation and apoptosis. In this review, various biological functions of CHK2 are reviewed, with emphasis on cell cycle control, apoptosis, attenuated angiogenic mimicvm formation and autophagy in tumor cells with p53 mutation. The summary of this review will help us to have a clearer and more comprehensive understanding of the biological functions of CHK2, and provide more effective treatment options for some diseases through the study of CHK2.
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