Research Progress on the effect of calcium overload on myocardial ischemia-reperfusion injury

Abstract

In the case of acute myocardial infarction, after coronary angioplasty, thrombolytic therapy and cardiac arrest and rebound surgery, the ischemic myocardium of patients may suffer from blood reperfusion injury. However, this is an inevitable complication of treatment, mainly manifested in arrhythmia, myocardial stunning, heart failure and so on, and even death in severe cases. The main mechanisms of myocardial ischemia-reperfusion injury include inflammatory response, autophagy, apoptosis, oxidative stress response, calcium overload, mitochondrial dysfunction and so on. What makes me curious is the calcium overload mechanism, which is the main inducement of reperfusion injury, and can act with other inducing mechanisms to further aggravate reperfusion injury. It is an important cause of myocardial injury and provides a new idea for myocardial protection. This paper comprehensively discusses calcium overload from the perspective of the mechanism of ischemia-reperfusion injury.