Abstract
PTEN is a tumor suppressor gene with dual specific phosphatase activity discovered after p53. and its deletion and mutation are closely related to the occurrence of a variety of malignant tumors. PTEN regulates cell proliferation, survival, and metabolism by inhibiting the activity of the PI3K/Akt signaling pathway, many components of which have been found to be involved in tumorigenesis. Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single gene copy of PTEN. In this paper, the data relating to PTEN loss in some common tumour types and the related treatment of tumors are reviewed.
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