Research progress on the correlation between primary aldosteronism and bone metabolism

Abstract

Primary aldosteronism is a clinical syndrome characterized by hypertension, with or without hypokalemia, low renin and hyperaldosteronism, which is a common endocrine hypertension due to adrenal cortical lesions and excessive autonomic aldosteronism, resulting in increased retention of sodium and potassium and volume load. Studies have shown that aldosterone overdose increases the risk of cardiovascular disease, renal insufficiency, diabetes, metabolic syndrome and even death. In recent years, studies have pointed out that patients with primary aldosteronism have increased urinary calcium and elevated parathyroid hormone, and the prevalence of osteoporosis and fracture is higher than that of essential hypertension and healthy people. Primary aldosteronism may be a secondary cause of osteoporosis, but the specific pathogenesis remains unclear. This article reviews the correlation of bone metabolism and possible pathogenesis of primary aldosteronism.