Abstract
Researchers are in constant search for the ideal implant surface condition in an attempt to improve osseointegration and to increase bone-to-implant contact. Although various techniques such as physicochemical and morphologic modification, have been proposed, they are still incapable of ensuring predictable results and guaranteed success. In recent years, investigators have also attempted to improve bone formation around implants via using biochemical modification. Various kinds of biomolecules have been introduced to endow the titanium surfaces bioactivities because of their certain bone-growth promoting capabilities. A review of the research progress is given in this paper concerning the biochemical modification of the implant surface.
Highlights
Nowadays, artificial implants, a third denture of human, can maximize the chewing efficiency of patients with missing teeth, delay the absorption of alveolar bone and improve the quality of life
Various kinds of bioactive molecules such as collagen, growth factor, peptides and DNA et al attract wide attentions in implant surface modification owing to their specific bioactive abilities, which have been proven to enhance and/or accelerate the process of osteoblastic function in vitro [11]
The results indicated that bone-like extracellular matrix (ECM) synthesized in vitro could enhance the osteoblastic differentiation of marrow stromal cells (MSCs)
Summary
Artificial implants, a third denture of human, can maximize the chewing efficiency of patients with missing teeth, delay the absorption of alveolar bone and improve the quality of life. Conventional physicochemical and morphologic treatments based on surface modifications like plasma spraying [5], alkaline treatment [6], hydroxyapatite coating [7], sandblasting and acid etching [8,9] are established, in order to improve osseointegration in bone healing process. Various kinds of bioactive molecules such as collagen, growth factor, peptides and DNA et al attract wide attentions in implant surface modification owing to their specific bioactive abilities, which have been proven to enhance and/or accelerate the process of osteoblastic function in vitro [11].
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