Abstract
Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i.e., immunoregulatory, antioxidative, anti-cancer, anti-diabetes, myocardial protective, hepatoprotective, and antiviral functions. This article reviews the protective effect and mechanism of astragaloside IV, which is extracted from Radix Astragali, on stroke, discusses the cerebroprotective effect of astragaloside IV against ischemia-reperfusion-related complications, offers insight into research prospects, and expands the idea of integrating traditional Chinese and Western medicine treatment strategies and drugs to provide a theoretical reference for the clinical treatment of cerebral ischemia-reperfusion injury and the improvement of stroke prognosis.
Highlights
Stroke has a high incidence and is the main cause of death worldwide
Recombinant tissue plasminogen activator, which is the only FDAapproved treatment for ischemic stroke, has a significant time-dependent therapeutic effect. rtPA is most effective when administered within 90 min before symptoms appear (Lansberg et al, 2009), and the prognosis of elderly patients and patients with severe stroke treated with rtPA is still poor (Saposnik et al, 2013)
After cerebral ischemia-reperfusion, the large number of free radicals produced by the brain have a severely damaging effect on nerve cells, and inhibition of the oxidative stress response is an important means for preventing ischemic injury
Summary
Stroke has a high incidence and is the main cause of death worldwide. Restoration of cerebral blood supply as soon as possible, i.e., reperfusion, is currently the best method for protecting the brain against ischemic injury. Astragaloside IV exerts a protective effect on neural stem cells by inhibiting the JNK/C-Jun pathway through miR-138.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
