Research progress on reprogramming induction of small molecules

Abstract

Abstract. In the fields of medicine and biology, tissue and organ transplantation is a key area of research for scientists. In order to meet the increasing demand for tissue and organ transplantation, the artificial induction of various types of tissue and organs has gradually become a research hotspot today. The gradual reprogramming of cells can generate transplanted organs without rejection reactions and enable low-cost testing of drug effects on the human body, which has broad prospects in medicine. At present, a large amount of research has been conducted on inducing organ transplantation through recoding, and a large amount of literature has been accumulated in preclinical studies, including the mechanisms and principles of its occurrence. There have been many attempts in inducing organ development in vitro, but there is no systematic summary and analysis of the relevant content. This article reviews the research progress of reprogramming to generate iPS, from the transfer of Yamanaka factors to the induction of small molecule reprogramming. Then, considering the current difficulty in screening new highly efficient inducible small molecules, this article used a reprogramming related protein.