Abstract
Brain metastasis is common in non-small-cell lung cancer (NSCLC) with driver gene mutations. At present, brain radiotherapy combined with tyrosine kinase inhibitor (TKI) is a hot topic. Anaplastic lymphoma kinase (ALK) gene rearrangement is one of the common driver mutations in NSCLC.However, the treatment of brain metastasis from NSCLC with ALK gene rearrangement has been rarely investigated. The prognosis of these patients, the role of brain radiotherapy and the proper combination of radiotherapy with ALK-TKI are worthy of further exploration. Key words: Anaplastic lymphoma kinase gene rearrangement; Lung neoplasm, brain metastasis/radiotherapy; Lung neoplasm, brain metastasis/target therapy; Progress
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