Abstract
Intestinal transplantation is the only treatment option for irreversible intestinal failure and parenteral nutrition failure. Although the progress of immunosuppressive therapy and the improvement of surgical techniques have improved the prognosis of intestinal transplantation, it is still unsatisfactory compared with other solid organ transplantation, mainly due to the fact that the intestinal mucosa is susceptible to damage due to ischemia. The basic pathophysiological process of ischemia-reperfusion injury(IRI) is that ischemia/reperfusion induces the production of reactive oxygen species (ROS), inflammation and cell apoptosis, leading to tissue damage. In recent years, the pathophysiology of ischemia-reperfusion injury in intestinal transplantation has made some new progress, providing more possibilities for the prevention and treatment of intestinal transplantation IRI.Although most of them are animal experimental results, they have important reference value for clinical application. Key words: Intestine, small; Organ transplantation; Reperfusion injury; Ischemic preconditioning; Review
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
