Abstract
Systemic inflammatory response syndrome (SIRS) is a pathophysiological process of critical children. It′s pathogenesis involved many sides such as immune dysfunction, gene expression regulation and intestinal barrier. By studying the regulation mechanism of SIRS, early diagnosis of SIRS can be made. According to the inflammatory status and each sides of pathogenesis, effective control results can be taken in time to stop the further developmentof SIRS and improve outcomes of critical children. Key words: [Key words]Systemic inflammatory response syndrome; Critical illness; Pathogenesis; Review
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