Research progress on inflammation and right ventricular failure

Abstract

Right ventricular failure (RVF) is the main cause of death in patients with cardiopulmonary disease, such as pulmonary arterial hypertension (PAH), pulmonary embolism, acute respiratory distress syndrome, and right ventricular infarction. The exact cellular and molecular mechanisms underlying RVF remains unclear. Inflammation may play an important role during the development of RVF, as it does in left heart failure. Cardiac inflammation has been shown in RVF patients and animal models, which played a role in the impairment of the right ventricular contraction and in the maladaptive remodeling. Inflammation plays a dual role in the development of cardiopulmonary disease and its anti-inflammatory therapies may have double benefits for RVF patients. This review summarizes the evidence of inflammation in RVF and research progresses of inflammation in the development of RVF to provide a reference for further exploring the mechanism of inflammation in RVF.