Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease

Abstract

In recent years, more and more studies have focused on the extra-digestive manifestations of Helicobacter pylori, and thyroid disease is a current hot spot. It has been confirmed that changes in the structure and composition of intestinal flora are related to the occurrence and development of autoimmune thyroid disease (AITD). When the intestinal flora is unbalanced, Helicobacter pylori colonizes the body through the damaged gut and releases special proteins that have similar amino acid sequences to thyroid antibodies. These proteins also destroy the metabolism of the body through molecular simulation and other mechanisms, attack the autoimmune system, especially the thyroid system, and ultimately lead to AITD. Therefore, Helicobacter pylori may play an important role in the pathogenesis of autoimmune thyroid disease, and this evidence may provide new ways to treat autoimmune thyroid disease.