Abstract

Low birth weight is associated with a higher risk of type 2 diabetes in later life,but the mechanisms are poorly understood.While the fetal insulin hypothesis indicates that insulin is an important growth hormone for fetal,genetic variants that are associated with the decrease of insulin secretion and function may account for some of the observed correlation between low birth weight and increased risk of type 2 diabetes.As a new means of studying complex disease genetics,genome-wide association studies (GWAS) has found many genetic loci which are related to low birth weight and type 2 diabetes.At present,it has confirmed that common genetic variants associated with low birth weight are LEKR1/CCNL1,ADCY5,CDKAL1,HHEX-IDE.Further more,ADCY5,CDKAL1 and HHEX-IDE are also susceptible genes of type 2 diabetes. Key words: Low birth weight; Type 2 diabetes mellitus ; Genetics

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