Abstract
Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is characterized by simultaneous degeneration of upper and lower motor neurons, resulting in muscle weakness, paralysis, and eventually death. However, research on its pathogenesis is currently unclear. Recently, many studies have found that the intestinal flora plays a direct or indirect role in the disease progression of ALS, including the release of neuroactive metabolites, increased intestinal permeability, and inducing metabolic disorders. Therefore, this article briefly reviews the correlation between intestinal microbiota and ALS in terms of pathology, aiming to provide new therapeutic targets for ALS.
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