Abstract
Cell membrane-coated biomimetic nanoplatforms have many inherent properties, such as bio-interfacing abilities, self-identification, and signal transduction, which enable the biomimetic delivery system to escape immune clearance and opsonization. This can also maximize the drug delivery efficiency of synthetic nanoparticles (NPs) and functional cell membranes. As a new type of delivery system, cell membrane-coated biomimetic delivery systems have broadened the prospects for biomedical applications. In this review, we summarize research progress on cell membrane biomimetic technology from three aspects, including sources of membrane, modifications, and applications, then analyze their limitations and propose future research directions.
Highlights
Traditional drug delivery primarily involves oral, intravascular, muscular, inhalational, or subcutaneous routes
This review introduces different cell membranes used in cell membrane technology, including erythrocyte membranes, leukocyte membranes, platelet membranes, stem cell membranes, cancer cell membranes, and hybrid membranes
With the widespread application of cell membrane biomimetic technology, modifications of cell membranes are being widely investigated as potential strategies
Summary
Cell membrane-coated biomimetic nanoplatforms have many inherent properties, such as bio-interfacing abilities, self-identification, and signal transduction, which enable the biomimetic delivery system to escape immune clearance and opsonization. This can maximize the drug delivery efficiency of synthetic nanoparticles (NPs) and functional cell membranes. As a new type of delivery system, cell membrane-coated biomimetic delivery systems have broadened the prospects for biomedical applications. We summarize research progress on cell membrane biomimetic technology from three aspects, including sources of membrane, modifications, and applications, analyze their limitations and propose future research directions
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