Abstract
Inflammation is a common and important clinical basic pathological process, and excessive inflammatory response has tremendous damage to tissues and organs.Carbon monoxide is a kind of small-molecular gas, which is generated by degradation of heme in the body.It has been demonstrated that endogenous carbon monoxide has a variety of biological activities involved in its cytoprotective efects, such as anti-inflammation, anti-apoptosis, anti-proliferation and vasodilation.Carbon monoxide has good anti-inflammatory effect in a variety of inflammatory models in basic research, which play roles in following main cell signal pathways include mitogen-activated potein kinase(MAPK) signal pathway, toll-like receptor(TLR) signal pathway, nuclear factor κappaB(NF-κB) signal pathway, janus kinase-signal transducer and activator of transcription(JAK-STAT) signal pathway.Unfortunately, carbon monoxide did not show good protective effect in clinical research.This review summarizes the anti-inflammatory mechanism of carbon monoxide, so as to provide theoretical reference for further study. Key words: Carbon monoxide; Anti-inflammation; Signal pathway; MAPK; NF-κB
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