Research Progress on Antibacterial Coatings for Preventing Implant-Related Infection in Fractures: A Literature Review

Abstract

Implant-related infection is a difficult problem in orthopaedics as it not only leads to failure in internal fixation, but also increases the financial burden and perioperative risk on patients. In the past, orthopaedic implants were designed as mechanical fixation devices simply to maintain mechanical and biological properties, not to regulate the surrounding biological microenvironment. More recently, antimicrobial biocoatings have been incorporated into orthopaedic implants to prevent and treat implant-related infections through the modulation of the local environment. This article reviews the application of orthopaedic-implant biocoating in the prevention of implant-caused infection. Although there are many candidate coatings, they are still in the preclinical testing stage, and thus additional research by biomaterials and clinicians is necessary to identify the ideal implant coatings for patients who require fracture surgery.