Abstract
Innate immunity is on the frontline of fight against pathogenic microorganism invasion. As a DNA sensor, absent in melanoma 2 (AIM2) is an important member of innate immune system. It can recognize dsDNA of pathogenic microbes to form AIM2 inflammasomes, which facilitates defending and clearing the invasion of pathogens by activating caspase-1 dependent pyroptosis and the mature of IL-18 and IL-1β. AIM2 inflammasomes play an important part in responding to Listeria monocytogenes, Francisella tularensis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Aspergillus fumigatus, vaccinia virus, murine cytomegalovirus, and hepatitis B virus infections. This paper introduces the components of AIM2 inflammasomes and summarizes its function in defending the invasion of pathogenic microorganisms. Key words: Absent in melanoma 2; Cysteinyl aspartate specific proteinase-1; Apoptosis-associated speck-like protein; Interleukin-18; Interleukin -1β; Pathogenic microorganism
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