Abstract
Streptococcus pneumonia (Spn) is the major pathogen of human disease.There are several virulence factors that are involved in the pathogenicity of Spn.With genetic studies and mutant strain applications,it contributes to a deep understanding of the classic pneunmococcal virulence factors and identification of novel virulence factors.This review discusses the biological activity and pathogenic mechanism of several pneumococcal virulence factors,including polysaccharide capsule,pilus,proteins and proteases. Key words: Streptococcus pneumonia; Virulence factors; Polysaccharide capsule; Pilus; Proteins and proteases
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