Research Progress of Traditional Chinese Medicine Intervention on HIF-2α in the Prevention and Treatment of Knee Osteoarthritis

Abstract

Knee osteoarthritis (KOA) is the most common chronic, degenerative and progressive osteoarthritis in clinical practice, which mainly manifests as knee pain, deformity and even joint function loss. With the advent of the global aging era, its incidence continues to increase, seriously occupying the medical resources of various countries. Its pathogenic factors are complex and its pathogenesis is not clear. How to effectively prevent and cure it has always been a hot topic in the medical field. Recent studies have found that the expression level of hypoxia inducible factor (HIIF) -2α plays an important role in regulating chondrocyte homeostasis, which is involved in the degradation of chondrocyte extracellular matrix and the generation of subchondral bone vessels, and accelerates cartilage degeneration. Studies have shown that the active ingredients of traditional Chinese medicine can regulate the expression of HIF-2α and slow down the development of knee osteoarthritis. This article reviews the related research on the prevention and treatment of knee osteoarthritis by the intervention of traditional Chinese medicine on HIF-2α expression, so as to provide scientific clinical basis and treatment plan for the later research on the treatment of KOA with traditional Chinese medicine.