Abstract
With the continuous progress and development in the biomedicine field, metallic biomedical materials have attracted the considerable attention of researchers, but the related procedures need to be further developed. Since the traditional metal implant materials are not highly compatible with the human body, the modern materials with excellent mechanical properties and proper biocompatibility should be developed urgently in order to solve any adverse reactions caused by the long-term implantations. The advent of the high-entropy alloy (HEA) as an innovative and advanced idea emerged to develop the medical implant materials through the specific HEA designs. The properties of these HEA materials can be predicted and regulated. In this paper, the progression and application of titanium-based HEAs, as well as their preparation and biological evaluation methods, are comprehensively reviewed. Additionally, the prospects for the development and use of these alloys in implant applications are put forward.
Highlights
In recent decades, bio-medical materials are widely used in implants and repair surgeries due to their high strength, wear, corrosion resistance, and biocompatibility (Saini, 2015)
The titanium-based high-entropy alloy (HEA) coatings deposited by laser cladding and magnetron sputtering exhibit good corrosion resistance and wear resistance, HEAs can be used as a potential coating on the surface of long-term implants
This study demonstrates that TiTaHfNbZr HEA coatings have a significant inhibitory effect toward the release of Ni ions
Summary
Bio-medical materials are widely used in implants and repair surgeries due to their high strength, wear, corrosion resistance, and biocompatibility (Saini, 2015). Titanium and its traditional alloys are ideal biomedical materials with good mechanical properties, biocompatibility, and corrosion resistance These materials are mostly used in orthopedics and dental implants Recent research have confirmed that the addition of Al and Cr to the alloy can effectively improve the oxidation resistance of HEAs, and the formation of some complex oxides can provide better protection for the alloy (Waseem and Ryu, 2020) This new type of alloy and its modern concept breaks the bottleneck of traditional material design and introduce new ideas for the research and development of high-performance metallic materials. It can deeply analyze the electronic structure and interatomic bonding of HEAs and has an important guiding significance for the design and application of medical HEAs in the future
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