Abstract

Neovascularization is significant for tumor growth and progression to malignancy. Tie2 expressing monocytes (TEM) are recruited into tumors by several growth factors and chemokines, and promote tumor angiogenesis in a manner of paracrine. Moreover, TEM, while stimulating tumor angiogenesis, do not actively incorporate into blood vessels as endothelial progenitor cells ( EPC) , but are incorporated in all new-forming blood vessel. TEM were found only in tumors and were missing in nonneoplastic tissues adjacent to tumors. Novel anticancer therapies that selectively target tumors by these cells have showed significant antitumor responses and near complete abrogation of metastasis. Key words: Tie2, Tie-2-expressing monocytes, Targeted anticancer therapy

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