Abstract
Double negative T cell is a kind of special regulatory T cell with a cell phenotype of TCR+ CD3+ CD4-CD8-. It plays an important role in many diseases such as autoimmune diseases, tumor immunity, transplant rejection and allergic diseases by expressing unique surface markers and secreting unique effector factors. Pancreatic cancer is a poorly diagnosed malignant tumor of the digestive system, and its early diagnosis rate is not high, the treatment is still based on radical tumor resection. Although the surgical technique is continuously improved, the 5-year survival rate has not improved significantly. At present, there is still a lack of effective treatment. In recent years, double negative T cell has become a new research hotspot in tumor immunity, bringing new hope for the treatment of pancreatic cancer. According to different types of T cell antigen receptor (TCR) expression, double negative T cell can be divided into TCRαβT cell and TCRγδT cell. This review focuses on the source of double negative T cell and possible molecular mechanisms in cancer therapy. Key words: Pancreatic neoplasms; Immunity; Double negative T cell
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