Abstract

Thalidomide has anti-tumor effects such as anti-tumor angiogenesis, improvement of immune function and cachexia of patients with advanced tumors, which has been effectively used in elderly patients with castration-resistant prostate cancer, chemotherapy resistant advanced colorectal cancer, advanced hepatocellular carcinoma and metastatic breast cancer. As the in-depth study of the anti-tumor mechanism of thalidomide, more and more clinical researches have focused on the function of thalidomide on non-hematological malignancies, especially it has obtained some achivements in the postoperative adjuvant therapy for high-risk colorectal cancer and primary hepatocellular carcinoma and the salvage therapy for metastatic triple-negative breast cancer and refractory gynecological tumor. Key words: Neoplasms; Therapeutic uses; Thalidomide

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