Abstract
靶向治疗是驱动基因阳性的晚期非小细胞肺癌重要的治疗手段之一，这个领域的治疗进展日新月异，包括新靶点的发现，新药物的问世以及靶向联合治疗方案的应用等，同时研究人员也深入地研究了各种靶向药物原发或获得性耐药机制。本综述旨在总结间变淋巴瘤激酶融合基因（anaplastic lymphoma kinase, ALK）及其他少见驱动基因阳性的非小细胞肺癌靶向治疗的新进展。
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