Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Tao Zhang,Ruyi Yang,Shengnan Yang,Jibin Guan,Dong Zhang,Yan Ma,Hongzhuo Liu

doi:10.1080/10717544.2018.1425776

Tao Zhang, Ruyi Yang + Show 5 more

Open Access

https://doi.org/10.1080/10717544.2018.1425776

Copy DOI

Abstract

Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and ‘switch-on/off’ mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine. A major section is used for biomedical applications of different nanogel systems based on modified pullulan, which exert smart stimuli-responses at ambient conditions such as charge, pH, temperature, light, and redox. Pullulan self-nanogels have found increasingly extensive application in protein delivery, tissue engineering, vaccine development, cancer therapy, and biological imaging. Functional groups are incorporated into self-nanogels and contribute to expressing desirable results such as targeting and modified release. Various molecules, especially insoluble or unstable drugs and encapsulated proteins, present improved solubility and bioavailability as well as reduced side effects when incorporated into self-nanogels. Finally, the advantages and disadvantages of pullulan self-nanogels will be analyzed accordingly, and the development of pullulan nanogel systems will be reviewed.

Highlights

The use of nanodrug delivery systems has resulted in significant advances in reduced toxicity, modified release, and enhanced treatment efficiency (Mura et al, 2013)
Kinetic analysis suggested that a two-step process of capturing bovine serum albumin (BSA) occurs, where initially, there is the fast pre-equilibrium of looser binding of BSA to the self-nanogel followed by the slower process of tighter inclusion into the hydrogel network (Nishikawa et al, 1996)
Many investigations have revealed that pullulan nanogel is a facile and efficacious delivery system

Summary

Introduction

The use of nanodrug delivery systems has resulted in significant advances in reduced toxicity, modified release, and enhanced treatment efficiency (Mura et al, 2013). Kinetic analysis suggested that a two-step process of capturing bovine serum albumin (BSA) occurs, where initially, there is the fast pre-equilibrium of looser binding of BSA to the self-nanogel followed by the slower process of tighter inclusion into the hydrogel network (Nishikawa et al, 1996) This illustrates that the stabilization of protein molecules within nanogel depends on molecular interactions, and when troubled in a segregated nanomatrix, the protein molecules will be more stable (Ayame et al, 2008). Shimoda designed a novel hybrid hydrogel with acryloyl group-modified CHP (CHPOA) nanogels as crosslinking domains, which were incubated with PEGSH at 37 C for 24 h under humidified conditions. It has been proven that nanogel-trapped agents such as liposome (Sekine et al, 2012), insulin (Shimoda et al, 2012b), and mouse embryonic fibroblasts (Hashimoto et al, 2015) were released from the hydrogel by degradation of CHPOA-PEGSH hydrogels that occurred by hydrolysis of the

Discussion

Conclusions

Disclosure statement