Abstract
As an induced mutant of genes, activation-induced cytidine deaminase (AID) deaminates cytosine deoxyribonucleotide into uracil deoxyribonucleotide resulting in gene mutation. Literatures report that AID plays an important role in the development and progression of leukemia.In recent years, lots of progress of AID protein structure and its mechanism, pattern of expression, prognostic significance, and imatinib resistance in leukemia have been made.This article reviews literatures on aforementioned aspects of AID. Key words: Activation-induced cytidine deaminase; Leukemia; Mutation
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Schedule a callMore From: International Journal of Blood Transfusion and Hematology
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