Abstract
DNA oxidative damage can lead to dysfunctions and diseases. There are many pathways to repair DNA oxidative damage and base excision repair (BER) is the most important one. 8-oxoguanine nucleotide triphosphatase, also known as MutT homologue (MTH)1, and 8-oxoguanine DNA glycosylase (OGG)1 are major repair enzymes, which are closely related with tumorigenesis and growth of tumor cells. This review is about the relationship among tumorigenesis, growth of tumor cells, therapy of neoplasms and DNA oxidative damage and the repair enzymes. Key words: DNA oxidative damage; DNA repair; Neoplasms; Therapy; 8-OxodGTPase; 8-Oxoguanine DNA glycosylase 1, zebrafish
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