Research progress of radiotherapy and molecular classifications of gastric cancer

Abstract

Adjuvant radiotherapy (RT) can improve the rate of loco-regional control for patients with gastric cancer (GC), while the selection of patients plays a key role. As the research moves along, several relatively comprehensive molecular classifications emerged such as the TCGA classification and the ACRG classification. Studies have demonstrated that molecular classifications are closely related to the clinicopathologic characteristics, prognosis and treatment response. However, there is not recognized molecular classification of GC presently. It is a great challenge for radiation oncologists to make use of the individual bioinformation and accurately select patients who would benefit from RT. Meanwhile, precision RT could also be achieved with the prediction of radiosensitivity, combination of RT with targeted therapy and the application of ctDNA within the field of RT. Key words: Stomach neoplasms/RT/PA; DNA, neoplasm; Review