Abstract
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a new high-risk subtype of acute lymphoblastic leukemia (ALL) proposed in recent years. It is characterized by a gene-expression profile similar to Ph-positive ALL, involving abnormal activation of cytokine receptor and tyrosine kinase, and commonly harbor genetic alterations targeting lymphoid transcription factors, and associated with a poor prognosis. Clinical studies showed that targeted inhibitors of related signaling pathways can significantly improve the prognosis in specific patients. The research progress of Ph-like ALL is summarized in this review. Key words: Philadelphia chromosome; Precursor cell lymphoblastic leukemia-lymphoma; Abelson murine leukemia virus; Prognosis; CRLF2 gene
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