Abstract
Cryptococcus neoformans(CN) is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system, resulting in devastating meningitis.The management of cryptococcal meningitis remains challenging because of its high mortality, the toxicity and uncertainty effect of antifungal therapy.In recent years, the study of the mechanism of neurotropism of CN has made a great progress.Many violence factors of this pathogen and several signal pathways of the host involved in this process have been discovered. Combination therapy with immunotherapy to regular antifungal treatment has become an important adjuvant method.The present review will concisely present current progress of pathogenesis and immunotherapy of cryptococcal meningitis. Key words: Cryptococcus neoformans; Blood brain barrier; Virulence factors; Immunotherapy
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