Research progress of multicentric Castleman disease

Abstract

Castleman disease is also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, which is a rare heterogeneous disease of lymphoid tissue. At present, reports related to Castleman disease are mostly small cases or case studies, which mainly focus on pathogenesis and treatment of multicenter Castleman disease (MCD), and some new developments have been achieved. Now, the research progress of the etiology, pathogenesis, clinical manifestation, diagnosis and treatment of MCD are reviewed. Key words: Giant lymph node hyperplasia; Lymphoproliferative disorders; Multicenter Castleman disease