Abstract
Due to the population aging, the rising incidence of age-related diseases such as diabetes, obesity and vascular diseases has led to an increase in the incidence of chronic wounds and a decrease in the cure rate. The current drugs and surgical treatments for chronic wounds have little effect except to prevent wound infection. In recent years, with the development of regenerative medicine represented by stem cells, new hope has been brought for the treatment of various refractory wounds. Mesenchymal stem cells (MSCs) were first isolated from bone marrow. They are the most widely and deeply studied types of adult stem cells. They have shown attractive application prospects in the treatment of wounds and have attracted wide attention in academic circles. This article reviews the research progress of MSCs in promoting chronic wound healing and summarizes the progress of preclinical and clinical research on MSCs in promoting wound healing in detail. The mechanisms that MSCs play a role in promoting wound healing, ie, immunomodulatory effects, in vivo differentiation and transdifferentiation, paracrine effects are described. Last but not least, the challenges and problems to be solved urgently in the MSCs treatment for chronic wound healing are also discussed in order to provided references and suggestions for further research. Key words: Mesenchymal stem cells; Wounds; Wound healing
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
