Abstract
Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the unitary ligand of Na + /K + ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention, increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na + /K + ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.
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