Research progress of lncRNA in the occurrence and metastasis of pancreatic cancer

Abstract

Pancreatic cancer is a malignant and gastrointestinal tumor. The five year survival for pancreatic cancer is very low. The pathogenic factors for pancreatic cancer are not yet clear. However, more and more studies have showed that lncRNAcontributed to pancreatic cancer proliferation and metastasis through genomic imprinting, chromatin modification, transcriptional activation and inhibition, nuclear transport, and protein function regulation. In recent years, with the continuous deepening of basic researches of pancreatic cancer, there were many long non-coding RNA deregulated in pancreatic cancer , which played an important role in tumororigenesis and metastasis. In this article, we reviewed the relevant researches on the mechanism of lncRNA in the occurrence and metastasis of pancreatic cancer. Key words: Pancreatic neoplasms; RNA, messenger; Signaling pathway; Neoplasm metastasis; Mechanism of action