Abstract
Hepatic veno-occlusive disease (HVOD) is one of the serious liver injury complications, and typical HVOD generally occurred within one month after hematopoietic stem cell transplantation (HSCT). The mechanism of HVOD is not entirely clear so far, and inflammation is one of the common factors affecting the HVOD. Inflammation is a response characteristic for injury, which depends on the innate immune cell activating and secreting interleukin (IL)-1α, -1β and tumor necrosis factor (IFN)-α. The inflammasome is the platform for proinflammatory cytokine hydrolysis activation, and determines the inflammatory injury degree. This review expounds research progress of inflammasomes in liver damage after HSCT. Key words: Hematopoietic stem cell transplantation; Hepatic veno-occlusive disease; Inflammation; Cytokines
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Blood Transfusion and Hematology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
