Research progress of IgA nephropathy markers

Abstract

IgA nephropathy is one of the most common forms of primary glomerulonephritis, and its clinical presentation and prognosis vary greatly among individuals, so early identification of individuals at high risk of poor prognosis is crucial. Currently, the clinical predictors of IgAN include hypertension, proteinuria, glomerular filtration rate and Oxford pathological staging, which are non-specific, invasive and delayed. With further research into the pathogenesis of IgAN, some new, simpler and earlier biomarkers have been identified. In this paper, the role of cytokine, protein and nucleic acid markers in the diagnosis of IgA nephropathy is described in a comprehensive manner based on the pathogenesis of IgA nephropathy. It is expected that based on the pathogenesis of IgA nephropathy, more markers of IgA nephropathy will be discovered by studying the four-fold strike doctrine and other related doctrines to help detect subclinical disease activity, monitor disease progression and assess treatment.