Abstract
Drug resistance and relapse are bottlenecks of acute myeloid leukemia(AML) treatment, and conquering the drug resistance of AML cells is the key to improving treatment and helping patients fully recovered. As an indispensably crucial chemotherapeutic agent of AML treatment, drug resistance of cytarabine is getting increasing attention. Recently, several studies had demonstrated that the incorrectly triggered hedgehog (Hh)-glioma-associated oncogene (Gli) signal pathway plays a significant role in the drug resistance of cytarabine. Furthermore, Gli gene over-expression is the marker of AML poor prognosis. The inhibitor of Hh-Gli signal pathway, especially Gli specific small molecular inhibitor GANT61 is capable of inhibiting growth and accelerating apoptosis of AML cells. Therefore, this aricle reviews literatures on the relationship between the signaling pathway of Hh-Gli and drug resistance of cytarabine in AML. Key words: Leukemia, myeloid, acute; Cytarabine; Drug resistance; Hedgehog-Gli signal pathway
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