Abstract
In recent years, studies have shown that galactose-deficient IgA1 (Gd-IgA1) antibodies are important in the pathogenesis of IgA nephropathy (IgAN). Serum levels of Gd-IgA1 antibodies are associated with levels of proteinuria and renal histological grading.Measuring the antibodies has guidance value in the diagnosis of IgAN, for its sensitivity and specificity can be up to 88%-89% and 89%-92% respectively.In addition, the antibodies play an important role in clinical prognosis, and it may provide a new direction for treatment in IgAN.Now, its role in prognosis of IgAN was reviewed. Key words: Galactose-deficient IgA1; Galactose-deficient IgA1 antibodies; IgA nephropathy
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