Abstract
过去的20年来，随着分子生物学研究的不断进展，非小细胞肺癌(non-small cell lung cancer, NSCLC)的治疗方法不断发展，靶向治疗使驱动基因突变阳性患者的生存期得到了改善。越来越多的靶点逐渐被发现，针对不同驱动基因的药物将NSCLC的治疗带入了一个前景广阔的靶向时代。在NSCLC的诸多驱动基因中，转染原癌基因(transfection proto-oncogene gene, RET)融合是除了表皮生长因子受体(epidermal growth factor receptor, EGFR)、间变淋巴瘤激酶(anaplastic lymphoma kinase, ALK)及c-ros原癌基因1-受体酪氨酸激酶(c-ros oncogene 1, receptor tyrosine kinase, ROS1)以外又一个重要的新兴靶点，针对RET基因融合的靶向药物不断推陈出新，近来新型高选择性RET抑制剂BLU-667和LOXO-292获得了重要突破。本文将对NSCLC中RET基因融合突变的概述、检测方法、临床病理特征、靶向治疗及耐药后的研究进展进行综述。
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