Abstract

Compared to preoperative imaging examinations, intraoperative visual detection, and palpation, fluorescence imaging technology offers excellent prospects for the field of precise surgical navigation due to its advantages in terms of immediacy, high resolution, and specificity. Fluorescent probes have shown great potential for more accurate delineation of tumor boundaries in image-guided surgery. This review aims to comprehensively analyze the current development status, research trends, and emerging frontiers of fluorescence imaging technology in intraoperative navigation. Based on the bibliometric analysis method of the VOSviewer software, this review analyzes the published articles on fluorescence imaging in the field of intraoperative navigation in the past 10 years (2012–2022). A total of 1073 articles related to intraoperative navigation using fluorescent probes were analyzed for specific characteristics, including publication year, authors, institutions, countries, references, and keywords. This study reveals current trends, global collaboration models, basic knowledge, research hotspots, and emerging frontiers of fluorescent probes in intraoperative navigation.

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