Abstract

阿霉素是一种用于血液和实体肿瘤治疗的一线化疗药物,但是阿霉素在癌症治疗中产生的心肌毒性限制了其应用。目前,没有一种药物能明确降低阿霉素的心肌损害。外泌体是由细胞分泌的生物性囊泡,在细胞之间物质交换和信号传递中起着重要作用。近年来,外泌体在心脏的保护作用被发现。也有研究表明,外泌体可以治疗阿霉素的心肌毒性。本文概述阿霉素心肌毒性的机制,并探究外泌体作为对抗阿霉素心肌毒性的辅助疗法的作用及其机制。.

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