Abstract
The epidermal growth factor receptor (EGFR) is a transmembrane receptor that induces cell proliferation, differentiation and is important in tumor growth, survival, and metastasis. The EGFR is highly amplified and expressed in Glioblastoma Multiforme (GBM), and the amplified EGFR exists in double minute chromosomes (DMs) in several GBM samples. In this review, we summarize the structure and functions of the EGFR, its effect on GBM, and the drugs targeting the EGFR. Key words: EGFR; GBM; DMs; Targeted therapy
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