Research progress of drosophila biological clock genes involved in sleep regulation

Abstract

The normal life activities of almost all living organisms are affected by the biological clock, and the key factor affecting it is the biological clock gene. Nowly, it is basically clear the molecular regulation mechanism of the clock gene, one of the more important is the two feedback mechanism of the molecular clock, they are respectively with per gene and tim gene constitute a feedback mechanism and a feedback mechanism with clk gene as the core, they are two interdependent transcription-translation feedback mechanism. The period, timeless, clock and cycle genes that have been found and studied thoroughly in drosophila have corresponding genes or obvious homologous genes in human body, and all play an important role in sleep-related diseases. Recently, studies on sleep-related diseases have mostly involved these four clock genes and detected genetic changes in one or more of them.Among these sleep-related diseases, Alzheimer's disease (AD) and obstructive sleep apnea syndrome(OSA) have been studied more.In this paper, the discovery of drosophila clock genes, molecular regulatory mechanisms and recent studies about the relationship between the clock genes and the sleep-related diseases will be briefly reviewed,and prospects for future treatment of sleep-related diseasess will be made on this basis.