Abstract

Diabetes cell therapy can restoreβcell function and provides the possibility to cure diabetes. Islet transplantation can achieve stable blood sugar level and is well tolerated. It also improves blood sugar metabolism, prevent the development of complications, and improve the quality of life. But the scarcity of donor pancreas and the need for long-term immunosuppression make the researchers to seek solution from pluripotent stem cells (PSCs) , which have the potential to reverse diabetes in diabetic mice. However, safety is the Achilles' heel of PSCs. In recent years, pancreatic progenitor cells were shown to stimulate acini cells orαcells to differentiate intoβcells, which can provide a new effective method for diabetes treatment. Key words: Diabetes; Pancreas; Islet transplantation; Pluripotent stem cells; Cell transdifferentiation

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